Can we stretch existing Covid vaccines to inoculate more people?
My (non-expert) opinion is still in favor of fractional dosing. Really needed more non-industry research on it though.
My (non-expert) opinion is still in favor of fractional dosing. Really needed more non-industry research on it though.
Aiming for 60% global vaccination rate by next March. Some interesting facts and notes around which countries produce/export vaccines.
Pending peer review, but apparently large benefit in waiting 12 weeks rather than three.
In donors without evidence of previous infection the peak antibody response was 3.5-fold higher in donors who had undergone delayed interval vaccination. Cellular immune responses were 3.6-fold lower.
Some loose-ish estimates, but some staggering figures in there.
16% of the world bought 70% of the vaccines. What force on earth could stop them? None, so we needed the massive supply increases, which were effectively banned.
What fraction of all vaccines were wasted?
- by excessive dosing. No sign of the dosing regimes changing despite strong evidence. 50-75%?**
- by bad needle design. 10-30% more.
Also includes some good links and references. And honest disclaimer from the author:
Note: I'm not a engineer, I'm not an economist, I'm not a pharmacologist, I'm not an epidemiologist. There will be something wrong with the above, no doubt in misunderstanding the nature of vaccine engineering bottlenecks.
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